Chlordiazepoxide, go-nogo successive discrimination and brain biogenic amines in cats
Identifieur interne : 001555 ( Main/Exploration ); précédent : 001554; suivant : 001556Chlordiazepoxide, go-nogo successive discrimination and brain biogenic amines in cats
Auteurs : Luc Vachon [Canada] ; Anne Kitsikis [Canada] ; Andrée G. Roberge [Canada]Source :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1982.
Abstract
Chlordiazepoxide (CDP; 0.4 mg/kg/day, per os) was administered to cats during either the acquisition (CDP 21–22 days) of a go-nogo successive discrimination task (SD) or the performance (CDP 10 days) of the previously learned SD task. Endogenous levels of serotonin, 5-hydroxyindoleacetic acid, noradrenaline and dopamine were assayed in 12 brain areas, in trained as well as in untrained cats. This study has shown that (1) CDP strongly impaired the acquisition but not performance of the SD task, revealing a dissociation of the effects of CDP on these two stages of training; (2) the CDP administration, as well as the SD training, produced regional changes in brain levels of biogenic amines, suggesting the involvement of particular monoaminergic neurons in the behavioral effects of CDP and in operant behavior; and (3) in particular brain areas, interactions were observed between the effects of the SD training and those of the CDP administration on monoamines, indicating that the behavioral state may interfere with the neurochemical effects of CDP.
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DOI: 10.1016/0091-3057(84)90093-5
Affiliations:
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Roberge</name><affiliation wicri:level="4"><orgName type="university">Université Laval</orgName><country>Canada</country><placeName><settlement type="city">Québec (ville)</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982">1982</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="9">9</biblScope><biblScope unit="page" to="22">22</biblScope></imprint><idno type="ISSN">0091-3057</idno></series><idno type="istex">5BD89C40A2104C784DC1615F55667FBBDFE6A385</idno><idno type="DOI">10.1016/0091-3057(84)90093-5</idno><idno type="PII">0091-3057(84)90093-5</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chlordiazepoxide (CDP; 0.4 mg/kg/day, per os) was administered to cats during either the acquisition (CDP 21–22 days) of a go-nogo successive discrimination task (SD) or the performance (CDP 10 days) of the previously learned SD task. Endogenous levels of serotonin, 5-hydroxyindoleacetic acid, noradrenaline and dopamine were assayed in 12 brain areas, in trained as well as in untrained cats. This study has shown that (1) CDP strongly impaired the acquisition but not performance of the SD task, revealing a dissociation of the effects of CDP on these two stages of training; (2) the CDP administration, as well as the SD training, produced regional changes in brain levels of biogenic amines, suggesting the involvement of particular monoaminergic neurons in the behavioral effects of CDP and in operant behavior; and (3) in particular brain areas, interactions were observed between the effects of the SD training and those of the CDP administration on monoamines, indicating that the behavioral state may interfere with the neurochemical effects of CDP.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Québec (ville)</li></settlement><orgName><li>Université Laval</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Vachon, Luc" sort="Vachon, Luc" uniqKey="Vachon L" first="Luc" last="Vachon">Luc Vachon</name></region><name sortKey="Kitsikis, Anne" sort="Kitsikis, Anne" uniqKey="Kitsikis A" first="Anne" last="Kitsikis">Anne Kitsikis</name><name sortKey="Roberge, Andree G" sort="Roberge, Andree G" uniqKey="Roberge A" first="Andrée G." last="Roberge">Andrée G. 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